Reinforcing effects of d-amphetamine
نویسندگان
چکیده
منابع مشابه
Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP.
3,4-methylenedioxymethamphetamine (MDMA) is a widely used drug of abuse chemically related to both the amphetamines and mescaline. Laboratory animal studies have shown that MDMA is a potent re-uptake inhibitor and releaser of dopamine and serotonin. Although the subjective and physiological effects of MDMA have been compared to d-amphetamine in humans, no direct comparison with a serotonin rele...
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It has recently emerged that there is a commonality in the molecular mechanisms underlying long-term neuronal changes in drug addiction and those mediating synaptic plasticity associated with learning and memory. In the hippocampus, the calcium-calmodulin-dependent protein phosphatase calcineurin plays a pivotal role in the molecular mechanisms that underlie learning and memory functions. Trans...
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Rationale: Amphetamine abuse by adolescents predicts long-term drug dependence. Heightened vulnerability to drug abuse could be due to higher sensitivity to drug’s reinforcing effects. Rodents are used to study age-related sensitivities to drugs. Objective: We compared intravenous amphetamine self-administration between adolescent and adult male rats on an operant schedule of reinforcement meas...
متن کاملRelationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs.
It has been reported that among drugs with mixed actions on central nervous system monoamine systems, increased serotonergic activity is associated with decreased potency as a reinforcer. The present experiment was designed to examine this relationship for amphetamine analogs that varied in serotonin releasing potency and to evaluate whether serotonergic actions can affect reinforcing efficacy....
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Rats were injected with either saline or 2 mg/kg of d-amphetamine 10 min prior to 50 trials of training with either the one-way, shuttle or shuttle-with-handling procedure. One-way training yielded more avoidances and shorter avoidance latencies than did either variant of shuttle training; it was not affected by the drug. The frequency of avoidances under shuttle training, on the other hand, wa...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2010
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e32833fa7b3